Process for preparation of 2-phenyl ethanol

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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Reexamination Certificate

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06979753

ABSTRACT:
The present invention provides an improved process for preparation of 2-phenyl ethanol. More specifically, the present invention relates to a process for preparing 2-phenyl ethanol by catalytic transfer hydrogenation of styrene oxide, in the presence of a supported transition metal catalyst. The catalyst system comprises of a palladium supported on silica, alumina, clay or charcoal.

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Ley, et al., “Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides”, Organic Letters, 5(24), 4665-4668 Coden: Orlef7; ISSN; 1523-7060, 2003, XP002291206.
Verqhese, et al. “Pd-catalyzed Regiospecific Reductive Ring Opening of Epoxides and Glycidic Esters”, Synthetic Communications, 25(15), 2267-73, Coden: Syncav; ISSN: 0039-7911, 1995, XP000892321.
Dragovich, et al., “Palladium Catalyzed, Regioselective Reduction of 1,2-Epoxides by Ammonium Formate”, J. Org. Chem., vol. 60, 1995, pp. 4922-4924, XP002291208.
Database Beilstein, 'Online! Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002291209.
Database Beilstein 'Online! Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002291210.
Database Beilstein 'Online! Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002291211 & Elsenbaumer et al., J. Org. Chem. vol. 46, No. 20, 1981, pp. 4034-4038.

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