Process for preparation of 13,14-dihydro-PGF2 alpha derivatives

Details Process for preparation of 13,14-dihydro-PGF2 alpha derivatives Process for preparation of 13,14-dihydro-PGF2 alpha derivatives

2011-03-01

2011-03-01

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S351000, C560S121000

Reexamination Certificate

active

07897793

ABSTRACT:
The invention relates to a process for the preparation of 13,14-dihydro-PGF2αderivatives of R or S configuration at carbon 15, represented by the general formula (I), wherein the identity of the substituents is defined in the description. Compounds of the formula (I) are valuable biologically-active substances or intermediates in the preparation thereof. The invention especially relates to the process for preparation of 13,14-dihydro-15(R)-17-substituted-18,19,20-trinor-PGF2α, i.e., latanoprost.

REFERENCES:
patent: WO 02/096898 (2002-12-01), None
Noyori et al. Angew. Chem. Int. Ed. Engl. 23 (1984) 847-876.
van Tamelen et al. Proc. Natl. Acad. Sci. USA, (82), 1879-1880, 1985.

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