Process for precursors to calcitriol and related compounds

Details Process for precursors to calcitriol and related compounds Process for precursors to calcitriol and related compounds

1993-03-19

1994-10-04

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 4, 549 53, 552505, 552541, 552544, 552546, 552547, 552548, 552552, 552653, C07C40100

Patent

active

053527810

ABSTRACT:
The process of the invention comprises reacting a C-22-halo-23,24-bisnorsteroid or C-22-halo-23,24-bisnor-9,10-secosteroid with a nickel complex of an electron withdrawing alkene of the formula ##STR1## wherein R.sub.1 is hydrogen, hydroxycarbonyl, lower alkoxycarbonyl, lower alkylcarbonyl or unsubstituted or substituted lower alkyl, and R.sub.2 is hydroxyl, lower alkoxy, or unsubstituted or substituted lower alkyl, to yield a C-25 or C-26 precursor of the formula ##STR2## which is appropriately functionalized for conversion into the corresponding steroid or secosteroid by treatment as hereinafter described.

REFERENCES:
patent: 3856780 (1974-12-01), Narwid et al.
patent: 4338250 (1982-07-01), DeLuca et al.
patent: 4772433 (1988-09-01), Hesse
patent: 4866048 (1989-09-01), Calverly, et al.
patent: 5110924 (1992-05-01), Halkes et al.
patent: 5182393 (1993-01-01), Yiannikouros et al.
patent: 5218109 (1993-06-01), Tsuji et al.
patent: 5225569 (1993-07-01), Yiannikouros et al.
Mascarenas, et al. Tetrahedron Letters, vol. 32, No. 4, p. 2813-2816 (1991).
Calverley, Tetrahedron, vol. 43, No. 20, pp. 4609-4619 (1987).
Mascarenas, et al. Tetrahedron, vol. 47, No. 20/21, pp. 3485-3498 (1991).
Andrews, et al. J. Org. Chem. vol. 51, pp. 4819-4828 (1986).
Marshall, et al. J. Org. Chem. vol. 51, pp. 1635-1637 (1986).
Yamada, et al. J. Org. Chem. vol. 48, pp. 3483-3488 (1983).
Schonecker, et al. Tetrahedron Letters, vol. 31, No. 9, pp. 1257-1260 (1990).

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