Process for polymerizing poly(lactic acid)

Details Process for polymerizing poly(lactic acid) Process for polymerizing poly(lactic acid)

1990-11-30

1991-12-24

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424422, 424426, 424484, 514964, A61K 914, A61K 922, A61K 952

Patent

active

050751158

ABSTRACT:
A process is provided for the condensation polymerizing lactic acid to a polymer with a weight average molecular weight of 2,500 to 4,500 containing less than 4% lactide and for a controlled release dosage form comprising a pharmaceutically active ingredient in a matrix of poly(lactic acid) and its copolymers with glycolic acid, valerolactone, .epsilon.-caprolactone, .epsilon.-decalactone, hydroxybutyric acid, .beta.-hydroxyvaleric acid and dioxanone.

REFERENCES:
patent: 4728721 (1988-03-01), Yamamoto et al.
Mark et al., Collected Papers of Wallace Hume Carothers on High Polymeric Substances, Interscience Publishers, Inc. (1940), pp. 152-153.

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