Process for piperidine intermediates for quinine, quinidine and

Details Process for piperidine intermediates for quinine, quinidine and Process for piperidine intermediates for quinine, quinidine and

1974-05-02

1976-01-06

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21102

Patent

active

039311929

ABSTRACT:
Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon.-carboxaldehyde, and a 4,5-crythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxylic acid and esters thereof. The end products are useful as antimalarial and antiarrhythmic agents.

REFERENCES:
morrison et al., "Organic Chemistry," 2nd Ed., Allyn and Bacon, Inc., Boston (1966), p. 1089.
Cram et al., "Organic Chemistry," 2nd Ed., McGraw-Hill, New York (1964), p. 415.

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