Process for phosphate ester compounds of certain cyclohexapeptid

Details Process for phosphate ester compounds of certain cyclohexapeptid Process for phosphate ester compounds of certain cyclohexapeptid

1991-07-30

1993-08-03

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530345, C07K 102, C07K 106, C07K 750

Patent

active

052330230

ABSTRACT:
A facile process for preparing a compound of the formula ##STR1## or a salt thereof, wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, X.sup.1 Y and Z are as defined in the specification, by direct phosphorylation of the corresponding phenolic compound with tetrabenzyl pyrophosphate in the presence of lithium hydroxide is described.

REFERENCES:
patent: 5021341 (1991-06-01), Giacobbe et al.
Khorana, H. G. et al., J. Chem. Soc. 1953, pp. 2257-2260.
Boehm, M. F. et al., Tetrahedron Letters, 29 (41), 5217-5220 (1988).

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