Process for pharmaceutical grade high purity hyodeoxycholic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

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C07C 3544, C07C 2992

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053490746

ABSTRACT:
Process for pharmaceutical grade high purity hyodeoxycholic acid preparation starting from swine bile, consisting in the treatment of swine bile with sodium hydroxide, isolation of hyodeoxycholic, chenodeoxycholic and hyocholic acids by precipiation of their zinc salts and subsequent selective precipitation of the hyodeoxycholic acid magnesium salt, from which the acid is freed by acidification and then crystallized.

REFERENCES:
patent: 2745849 (1956-05-01), Fogle
patent: 4163744 (1979-08-01), Kaiser
patent: 4186143 (1980-01-01), Ziegler et al.
patent: 4217279 (1980-08-01), Kaiser

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