Process for performing retro-aldol reaction

Details Process for performing retro-aldol reaction Process for performing retro-aldol reaction

1996-12-10

1997-10-14

Achutamurthy, Ponnathapura

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Chemical aftertreatment, e.g., acylation, methylation, etc.

530317, 530402, 530406, 530300, 568308, 568414, 562463, 562577, 560 53, 560 171, 564169, 564199, 561443, 561502, C07K 1107, C07C 6747

Patent

active

056774230

ABSTRACT:
A process for removing .beta.-hydroxy groups from .beta.-hydroxy-containing compounds is disclosed. The process involves the use of a retro-aldol-promoting reagent selected from the group of trimethylamine-N-oxide, triethylamine-N-oxide, trimethylamine-N-oxide-hydrate, and trimethylamine-hydrate and requires dissolution of the substrate in an aprotic solvent and reaction under elevated temperatures. The process is broadly applicable to a variety of substrates including complex cyclic peptides, linear peptides, and non-peptides.

REFERENCES:
patent: 5057493 (1991-10-01), Takesako et al.
patent: 5059540 (1991-10-01), Bailey
patent: 5158876 (1992-10-01), Takesako et al.
patent: 5200505 (1993-04-01), Takesako et al.
patent: 5260214 (1993-11-01), Takesako et al.
J. Org. Chem., 1981, 46, 4789-4791.
J. Antibiotics, Sep. 1991, vol. 44, No. 9, 925-933.
J. Antibiotics, Sep. 1991, vol. 44, No. 9, 919-924.
J. Molecular Structure (Theochem), 180 (1988) 383-387.

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