Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1994-04-04
1996-03-26
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530338, 530339, 562443, 562553, 564138, 564164, 564193, 564198, C07C23102, C07K 108
Patent
active
055021654
ABSTRACT:
The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in the presence of a coupling reagent and an additive. This process is useful for making ubiquitous amides and polypeptides having various biological activities.
REFERENCES:
patent: 3870694 (1975-03-01), Fujino et al.
patent: 4755591 (1988-07-01), Konig et al.
patent: 5166394 (1992-11-01), Breipohl et al.
Nozaki, S. et al., Chem. Lett. 1977, 1057-1058, entitled, Rapid Peptide Synthesis in Liquid Phase. Preparation of Angiotension II as an Example.
Nozaki, S. & Muramatsu, I., Bull. Chem. Soc. Japan, 1982, 55,2165-2168, entitled, Rapid Peptide Synthesis in Liquid Phase, Preparation of Angiotension II and Delta-sleep-inducing Peptide by the "Hold-in-Solution" Method.
Schneider, C. H. and Wirz, W., Helv. Chim. Acta, 1972, 55, 1062-1074, entitled, Antigen Synthesis: The Preparation of Selected Dodecapeptide Carriers with Systematically Altered Structures by a Two-Phase Method.
Sheehan, J. C., et aL., J. Am. Chem. Soc., 1965, 87, 2492-2493, entitled, A Rapid Synthesis of Oligopeptide Derivatives Without Isolation of Intermediates.
Fujino, M. et al., Chem. Pharm Bull., 1974, 22(8), 1857-1863, entitled, The Use of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Esters in Peptide Synthesis.
Carpino, L. A., J. Am. Chem. Soc., 1993, 115, 4397-4398, entitled, 1-Hydroxy-7-azabenzotriazole. An Efficient Peptide Coupling Additive.
Emerson Khateeta
Ho Guo-Jie
Mathre David A.
Song Zhiguo
Appollina Mary A.
Merck & Co. , Inc.
Russel Jeffrey E.
Winokur Melvin
LandOfFree
Process for peptide segment condensation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for peptide segment condensation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for peptide segment condensation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-916698