Process for penems

Details Process for penems Process for penems

1994-02-22

1995-05-16

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514192, 514195, A61K 31425, C07D49900

Patent

active

054162084

ABSTRACT:
Antibacterial penems of formula (I), where R represents a hydrogen atom or a hydroxy protecting group, are prepared by reacting a .beta.-lactam of formula (II) with an oxalyl halide in an inert solvent in the presence of an organic or inorganic base or an acid scavenger to produce a compound of formula (III), wherein X is a halogen atom, treating the resultant compound of formula (III) with a 1,3-dioxolen-2-one of formula (IV), wherein Y is a hydroxy group, in the presence of molecular sieves or an organic or inorganic base to produce a compound of formula (V), and cyclizing the compound of formula (V) in the presence of a trialkylphosphite to provide the penems of formula (I).

REFERENCES:
patent: 4952577 (1990-08-01), Alpegiani et al.
Chemical Abstracts, vol. 102, No. 25, 24 Jun. 1985, (Columbus, Ohio, US) see p. 593, abstract No. 220862x & JP, A, 59212488 (Kyoto Pharmaceutical Industries, Ltd.) 1 Dec. 1984.
Marco Alpegiani et al, "On the Preparation of 4-Hydroxymethyl-5-Methyl-1,3-Dioxol-2-One," Synthetic Communications, 22(9), pp. 1277-1282 (May 1992).
Marco Alpegiani et al, "Synthesis and Biological Properties of FCE 25199, A New Oral Penem," The Journal of Antibiotics, vol. 45, No. 5, pp. 797-801, (May 1992).

Affiliated with

Also associated with

Rating

Process for penems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for penems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for penems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-638723