Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2007-05-01
2007-05-01
Achutamurthy, P. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S004000, C435S006120, C435S025000, C435S440000, C536S023200, C536S023700, C514S789000
Reexamination Certificate
active
09856339
ABSTRACT:
A process for oxidizing a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidizing said compound with a mutant haem-containing enzyme, the mutant comprising the substitution of an amino acid in the active site by an amino acid with a less polar side-chain. The enzyme is typically P450camor P450BM-3. Cells and libraries of cells in which the process can be carried out or which can be used to select advantageous mutant enzymes are also provided.
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Bell Stephen Graham
Carmichael Angus Bishop
Wong Luet Lok
Achutamurthy P.
Fulbright & Jaworski LLP
ISIS Innovation Limited
Pak Yong D.
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