Process for oxidation of 4-amidotetrahydrobenzo [b]-thiophenes t

Details Process for oxidation of 4-amidotetrahydrobenzo [b]-thiophenes t Process for oxidation of 4-amidotetrahydrobenzo [b]-thiophenes t

1978-04-04

1980-04-22

Siegel, Alan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260326R, 260586P, 549 59, 549 75, C07D20934, C07C 4500, C07D33324, C07D33316

Patent

active

041995104

ABSTRACT:
There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobaltic carboxylate reactant and in the absence or presence of air, a compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a substituent selected from the group consisting of alkanoyl C.sub.1 -C.sub.7, halogen-substituted alkanoyl C.sub.1 -C.sub.7, carboalkoxy C.sub.1 -C.sub.4, ##STR2## and ##STR3## R.sub.3 is selected from the group consisting of hydrogen and alkyl C.sub.1 -C.sub.4 ; R.sub.4 is selected from the group consisting of hydrogen, alkyl C.sub.1 -C.sub.8, alkanoyl C.sub.2 -C.sub.4, halogen-substituted alkanoyl (C.sub.2 -C.sub.4), and ##STR4## and when the ##STR5## moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C.sub.1 -C.sub.4 ; the racemic mixtures and the optical isomers thereof.

REFERENCES:
patent: 2223494 (1940-12-01), Loder
patent: 2386372 (1945-10-01), Wagner
patent: 3317592 (1967-05-01), MacLean
patent: 3946079 (1976-03-01), Paasen
patent: 3994924 (1976-11-01), Asato

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