Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) hep

Details Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) hep Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) hep

1989-12-21

1991-05-07

Waddell, Frederick E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

548566, C07D20746, C07D48708

Patent

active

050138391

ABSTRACT:
1S,4S and 1R,4R-2-alkyl-2,5-diazabicyclo[2.2.1]-heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.

REFERENCES:
patent: 3196154 (1965-07-01), Steck
patent: 3328396 (1967-06-01), Kirchner
patent: 3951980 (1976-04-01), Henry et al.
patent: 4775668 (1988-10-01), Jefson et al.
Synthesis of CIS and Trans Isomers of 4-Chloro-L-Proline, 4-Bromo-Proline, and 4-Amino-2-Proline, R. H. Andreatta et al., Australian Journal of Chemistry, 1967, (20), pp. 1493-1509.
The Preparation of CIS-and Trans-4-H.sup.3 -L-Prolines and their use in Studying the Mechanism of Enzymatic Hydroxylation in Chick Embryos, Fujita et al., JACS, (86), Nov. 1964, pp. 4709-4716.
[.sup.18 F]Flourine Labeled Aliphatic Amino Acids, M. van der Ley, J. Labelled Cmpds. and Radiopharmaceuticals, (20), 4, pp. 453-461, (1983).
Portoghese, et al., J. Org. Chem., 31, 1059-1062, (1966).
Fujita, et al., J. Am. Chem. Soc., 86, 4709-4716, (1964).
Baker, et al., J. Org. Chem., 46, 2954-2960, (1981).
Andreatta, et al., Aust. J. Chem., 20, 1493-1509, (1967).
Van der Ley, J. Labelled Copounds and Radiopharmaceuticals, 20, 453-460, (1983).

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