Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Egg enclosed in shell or a part thereof
Patent
1995-09-27
1997-09-23
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Egg enclosed in shell or a part thereof
424DIG13, 426601, 426641, 426425, 426492, A61K 3554
Patent
active
056701756
DESCRIPTION:
BRIEF SUMMARY
A substantial disadvantage shared by the many customary pharmaceuticals for the treatment of skin burns, in particular sunburn, which are prepared on an industrial scale by the prior art is that the active substances used lack stability to decomposition. The same applies to a large number of commercially available cosmetic preparations for skin regeneration. As a rule, this results in the necessity of having to add to these products preservatives during the production process which facilitate long-term storage of the product, or even make it possible in the first place. However, the fact that such preserving additives have potential side effects which are difficult to estimate and can frequently not be fully delimited or even predicted, is frequently a decidedly undesirable risk factor for the user of the pharmaceuticals. Bearing in mind that there is an increasing occurrence of civilizational skin disorders, in particular a striking increase in the occurrence of all sorts of skin allergies, it is desirable to effectively delimit or, as far as possible, to fully eliminate the spectrum of potential health hazards presented by preserving additives in pharmaceuticals of the type mentioned at the outset.
The present invention describes a process for the preparation of an ultrapure egg oil which can be obtained from avian or reptilian egg yolk. Being natural, the product can be employed for the therapy of all sorts of skin burns, including sunburn, and also as an active substance for regenerating diseased areas of the skin, or areas of the skin which are affected due to particular stress. In this context, it must be stressed that the invention, which involves a multi-step purification process, eventually leads to an ultrapure product which allows any preserving additives for improving storage stability to be dispensed with completely. Since the product does not depend on stabilizing preservatives, it is possible to completely rule out all the above-described side effects and health hazards. process steps, the aim of obtaining an ultrapure egg oil only being achieved by their totality and the sequence indicated. Accordingly, the process is characterized by the following process steps: the dried egg yolk to give a pulverulent product (A), to seven days using a fat-dissolving extractant, a period of up to 10 hours, preferably for five to seven hours, 12.degree. C. over a period of up to 24 hours until distinct phase separation takes place, in step (e), 40 minutes at a speed of up to 7,000 revolutions per minute, and separating off the less viscous phase (D), a ratio of 1:2 to 1:5 by volume, and heating the mixture over a period of 30 to 90 minutes at a temperature of 90.degree. to 120.degree. C., preferably 95.degree. to 100.degree. C., and separating off the less viscous component (E), at a speed of up to 7,000 revolutions per minute, and separating off the less viscous phase (F), 7.degree. to 12.degree. C. over a period of up to 24 hours until distinct phase separation takes place, and separating off the less viscous phase (G), at a speed of up to 7,000 revolutions per minute, and separating off the less viscous phase (H), using the product (H) obtained in step (1). the egg yolk of birds, such as chickens, ducks, ostriches and the like, or, alternatively, of reptiles, such as, for example, turtles. This starting material is dried in a first process step (a) at temperatures of not more than 90.degree. C., preferably between 50.degree. C. and 70.degree. C. On an industrial scale, dried egg yolk is, as a rule, prepared in a so-called falling-film tower; alternatively, drying ovens, for example those operating with circulating air, are also suitable. The dried egg yolk is comminuted to a mean particle size of between, for example, 0.3 and 1.0 mm; for example, it is passed with pressure through a screen in the form of a narrow-meshed metal wire gauze (10.times.10 up to 30.times.30 mesh per cm.sup.2). process (b) using a fat-dissolving extractant, which should be affected over a period of three to seven days, but pref
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