Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Separation or purification
Patent
1984-11-15
1989-03-28
Wiseman, Thomas G.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Separation or purification
530300, 536 22, 536 23, 536 24, 536 27, 514 2, 514 7, 514 8, 424 88, 424 89, 424 92, 424105, 435 68, A61K 3900, A61K 3902, A61K 3912, C07H 1512
Patent
active
048165638
ABSTRACT:
Antigen specific excreted transfer factor may be obtained by collecting material, e.g. colostrum or milk, secreted by the mammary gland of a suitable lactating mammal, e.g. a cow having immunity to the antigen under suitable conditions such that materials which interfere with transfer factor efficacy are removed so as to obtain transfer factor. Colostrum or milk so collected may be used directly, typically after sterilization, or may be treated to further concentrate and/or purify transfer factor. Treatment to yield colostral whey containing transfer factor is presently the preferred method for obtaining transfer factor for use in conferring immunity against diseases associated with antigens for which the transfer factor is specific. Cell-associated transfer factor specific for an antigen may also be obtained by incubation release from, or lysis of, cells obtained from the collected material. An alternative method for obtaining transfer factor is to recover it from the mammary tissue of a suitable lactating mammal. The transfer factor may be used in edible compositions and in pharmaceutical or veterinary compositions and in methods for conferring immunity in a human or lower animal to a disease associated with the antigen. The transfer factor may then be used to prevent or treat the disease.
REFERENCES:
France et al Clin Res, vol. 28 863 A 1981 "Transfer Factor from Human Colostrum and Breast Milk Lymphocytes".
Ruben et al Clin Res vol. 27(4) 1979 698 A "Cell Medicated immunity to influenza A virus and influenza B virus in human colostrum and milk".
Meggs et al Am J. Obstet Gynecol vol. 133(6) 1979, pp. 703-707 "In-vitro Stimulation of human colostral lymphocytes by cytomegalovirus".
Parmely et al J. Dairy Science vol. 60(4) 1977 pp. 655-665 "Colostral cell medicated immunity and the concept of a common secretory immune system".
Schlesinger et al Lancet vol. 2 1977 pp. 529-532 "Evidence for transmission of lymphocytes response to tuberculin by breast feeding".
Wilson et al Immunobiology of Transfer Factor 1983 Kirkpatrick, Colt et al editors p. 331.
Wilson et al. Immunology Today vol. 4, p. 157.
Paddock Gary V.
Wilson Gregory B.
Amtron, Inc.
Santalone John J.
Teskin Robin L.
White John P.
Wiseman Thomas G.
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