Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1989-01-13
1990-06-12
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530402, 530404, 530406, 530408, 530409, 530410, 530412, 530418, 530422, C07K 308
Patent
active
049334344
ABSTRACT:
The present invention provides a process for the renaturation of denatured proteins in solution in a renaturation buffer, wherein a solution is prepared of the protein to be renatured in the critical concentration in a selected buffer and, after formation of the folding intermediate, further protein to be renatured is added in the amount necessary for the achievement of the critical concentration.
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Merge et al., "Purification of Proteins From Cell Culture Supernatants", Develop Biol. Std., vol. 66, 1987, pp. 391-401.
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Jaenicke, Biophys Struct Mech 8: 231-256 (1982).
Fischer Stephan
Rudolph Rainer
Boehringer Mannheim GmbH
Draper Garnette D.
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