Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reissue Patent
2007-10-16
2007-10-16
Davis, Zinna N. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reissue Patent
active
11022424
ABSTRACT:
The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.
REFERENCES:
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4761479 (1988-08-01), Goel et al.
patent: 892552 (1982-09-01), None
Bartra Sanmarti Marti
Llagostera Montserrant Monsalvatje
Navarro Jaime Thomas
Puig Torres Salvador
Davis Zinna N.
Esteve Quimica S.A.
Morgan & Finnegan L.L.P.
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