Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1986-07-11
1988-06-28
Weimar, Elizabeth
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
530419, 530806, 530825, 536127, A61K 3902, A07K 302, A07K 312, A07K 324
Patent
active
047537965
ABSTRACT:
The invention provides a process for the insulation of an antigenic composition substantially free from cells and lipopolysaccharide, the said composition comprising a complex having a polysaccharide constituent and a protein constituent, wherein the polysaccharide constituent comprises capsular polysaccharide specific to serogroup B of N. meningitidis, and the protein constituent comprises N. meningitidis outer-membrane protein selected from the class consisting of those proteins specific to serotype 6, those proteins specific to serotype 2 and having a single dominant component having a molecular weight of 42,000.+-.3,000, and immunological equivalents of such proteins. Preferably the composition also comprises a pharmacologically acceptable metal either as an adjuvant in admixture with the polysaccharide-protein complex, or in complex therewith to provide a triple metal-polysaccharide-protein complex. The composition is useful for the prophylaxis or treatment of bacterial disease in mammals such as man.
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Lifely Mark R.
Moreno Carlos
Brown Donald
Burroughs Wellcome Co.
Weimar Elizabeth
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