Process for obtaining medically active fractions from sea cucumb

Details Process for obtaining medically active fractions from sea cucumb Process for obtaining medically active fractions from sea cucumb

1996-08-05

1999-03-02

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

4241951, 424572, 514783, 514822, 514825, 514885, A61K 3512, A61K 3578

Patent

active

058767622

ABSTRACT:
The invention concerns fractions from echinoderms of the class Holothuroidea (sea cucumber) that can be used directly as active therapeutic agents or as raw materials in producing biologically active derivatives thereof. The fractions can be used alone or in combination and are derived from a) the epithelial layer, free of muscle and collagenous tissues, b) the isolated flower, or c) the whole body wall substantially free muscle, viscera and flower. The invention also concerns processes for obtaining these fractions that involve the use of thermal/mechanical and/or enzymatic means.

REFERENCES:
patent: 3405120 (1968-10-01), Kawano et al.
patent: 4900815 (1990-02-01), Tanaka et al.
patent: 5519010 (1996-05-01), Fan et al.
Kalyani et al., "Holothurin--A Review", Ind. J. Natl. Prod., vol. 4(2): 3-8, 1988.
Mourao et al., "Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm", Journal of Biological Chemistry, vol. 271, No. 39, pp. 23973-23984, 1996.
Matsumura et al., "Disaggregation of Connective Tissue: Preparation of Fibrous Components from Sea Cucumber Body Wall and Calf Skin", J. Biochem., vol. 73: 155-162, 1973.
Santhakumari et al., "Antimitotic effects of Holothurin", Cytologia, vol. 53: 163-168, 1988.
Miyamoto et al., "Six Newly Identified Biologically Active Triterpenoid Glycoside Sulfates from the Sea Cucumber Cucumaria echinata", Liebigs. Ann. Chem., pp. 453-460, 1990.
Pettit et al., "Antineoplastic Agents XLV: Sea Cucumber Cytotoxic Saponins", Journal of Pharmaceutical Sciences, vol. 65(10): 1558-1559, 1976.
Anisimov et al., "Comparative Study of Cytotoxic Activity of Triterpene Glycosides from Marine Organisms", Toxicon, vol. 18: 221-223, 1980.
Rodriguez et al., "Holothurinosides: New Antitumor Non Sulphated Triterpenoid Glycosides From The Sea Cucumber Holothuria Forskalii", Tetrahedron, vol. 47, No. 26, pp. 4753-4762, 1991.
Sumi et al., Comp. Biochem. Physiol., B: Comp. Biochem. 102(B):163-172. Abstract Only, 1992.
Yaacob et al., Malaysian Applied Biology, 24(1):23-28. Abstract Only, 1995.
Rodriguez et al., Tetrahedron, 47/26:4753-4762. Abstract Only, 1991.
Miyamoto et al., Liebigs Ann. Chem., 5:453-460. Abstract Only, 1990.
Santhakumari et al., Cytologia(Tokyo), 53(1):163-168. Abstract Only, 1988.
Kuznetsova et al., Comp. Biochem. Physiol. C Comp. Pharmacol., 73(1):41-44. Abstract Only, 1982.
Pettit et al., J. Pharm. Sci., 65(10):1558-1559. Abstract Only, 1976.
Vieira, Ricardo P., Occurrence of a Unique Fucose-branched Chondroitin Sulfate in the Body Wall of a Sea Cucumber. J. Biol. Chem., 263(34):18176-18183 (1988).
Mulloy, Barbara et al., Sulfated Fucans from Echinoderms Have a Regular Tetrasaccharide Repeating Unit Defined by Specific Patterns of Sulfation of the 0-2 and 0-4 Positions. J. Biol. Chem., 269(35):22113-22123 (1994).
Vieira, Ricardo P., et al., Structure of a Fucose-branched Chondroitin Sulfate from Sea Cucumber. J. Biol Chem., 266(21):13530-13536 (1991).
Eylers, John P., Ion-Dependent Viscosity of Holothurian Body Wall and Its Implications for the Functional Morphology of Echinoderms. J. Exp. Biol., 99:1-8 (1982).
Findlay, John A., et al., Frondogenin, A New Aglycone From the Sea Cucumber Cucumaria Frondosa. J. Natural Prod., 47(2):320-324, Mar.-Apr. (1984).

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