Process for obtaining insulin like active substances

Details Process for obtaining insulin like active substances Process for obtaining insulin like active substances

1976-12-09

1978-04-18

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, A61K 3514, A61K 3516, A61K 3702

Patent

active

040852040

ABSTRACT:
The invention concerns a novel process for obtaining insulin-like active substances from blood or a blood component of a warm-blooded animal, which comprises the steps of pre-treating the blood or blood component by adjusting the pH thereof to a value of from 2 to 4 or of from 8 to 10, incubating the pre-treated blood at a temperature of from about 15.degree. to about 40.degree. C for a period of at least four hours, cooling the incubated blood to a temperature of less than 10.degree. C, and recovering from the treated blood after neutralization organic peptide substances having a molecular weight of from about 1000 to about 5000, and an insulin-like activity of from about 14 to about 40 .mu.U/mg solid.

REFERENCES:
chem. Abst. Gen. Subject Index, vol. 81, (1974), p. 179gs.

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