Process for obtaining enantiomers of 2-arylpropionic acids

Details Process for obtaining enantiomers of 2-arylpropionic acids Process for obtaining enantiomers of 2-arylpropionic acids

1989-05-01

1990-11-27

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548224, C07B 5500

Patent

active

049737457

ABSTRACT:
A process for obtaining enantiomers of 2-arylpropionic acids by reacting a racemic mixture thereof with an amine-enantiomer, which process comprises converting the racemate of the 2-arylpropionic acid with an optically active form of threo-1-p-nitrophenyl-2-aminopropane-1,3-diol into the diastereomeric salts, separating these salts and converting the thus-obtained pure diastereomers into the free acids of the enantiomer forms of the 2-arylpropionic acid or into the salts thereof.

REFERENCES:
patent: 4209638 (1980-06-01), Nicholson et al.
patent: 4621152 (1986-11-01), Bernini
patent: 4675054 (1986-11-01), Bernini
S. S. Adams, et al., "Pharmacological Difference Between the Optical Isomers of Ibuprofen: Evidence for Metabolic Inversion of the (-)-Isomer." J. Pharm, Pharmac., 28: 156-157, 1976.
F. Hanakum et al., "Pharmacokinetics of Ibuprofen Enantiomers in Humans Following Oral Administration of Tablets with Different Absoprtion Rates." Pharm. Res., 5(1): 40-43, 1988.

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