Process for obtaining delta antigen of hepatitis D virus and use

Details Process for obtaining delta antigen of hepatitis D virus and use Process for obtaining delta antigen of hepatitis D virus and use

1984-02-16

1986-10-28

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435805, 435810, 436528, 436529, 436530, 436543, 436804, 436807, 436808, 436809, 436810, 436811, 436820, 436825, 436826, G01N 3353, G01N 33544, G01N 33531

Patent

active

046198962

ABSTRACT:
A process for `unmasking` delta antigen in the blood of an animal, known or caused to be infected with the antigen. The process involves treating serum from the animal with a surfactant and optionally with an antibody--antigen dissociating agent. The blood derived delta antigen is used as a diagnostic agent in the detection and determination of different classes of antibodies to hepatitis D. virus (delta agent) by enzyme-immunoassay and radio-immunoassay.

REFERENCES:
Bonino et al, Infection and Immunity, 43 (1984) 1000-5.
Marion et al, Proc. Nat'l. Acad. Sci. USA 77 (1980) 2941-5.
Rizzetto et al, J. Immunol. 125 (1980) 318-24.
Rizzetto et al, Lancet vol. II (1979) #8150, pp. 986-990.
Imedile et al, Lancet, vol. II (1982) #8305, pp. 945-947.
Rizzetto et al, J. Infec. Dis. 141 (1980) 590-602.
Raimondo et al, Br. Med. J. 286 (1983) 845.
Rizzetto et al, Proc. Natl. Acad. Sci. USA, 77 (1980) 6124-8.
Rizzetto, "Hepatology", vol. 3, No. 5, pp. 729-737 (1983).
Shattock et al, "Journal of Medical Virology", vol. 13, pp. 73-82 (1984).
Govindarajan et al, "Journal of Medical Virology", vol. 14, pp. 33-37 (1984).
Shattock et al, "British Medical Journal", vol. 290, pp. 1377-1380 (1985).

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