Process for obtaining D(+)-naproxen

Details Process for obtaining D(+)-naproxen Process for obtaining D(+)-naproxen

1986-10-27

1989-08-15

Schenkman, Leonard

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435280, C12N 918, C07P 4100

Patent

active

048574627

ABSTRACT:
A process for obtaining D-2-(6-methoxy-2-naphthyl)-propionic acid from a mixture of D- and L-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl esters is provided by asymmetric hydrolysis of the L-ester with a microbial enzyme, separation of the 2-(6-methoxy-2-naphthyl)-propionic acid from the D-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl ester and saponification of the latter, wherein the saponification is carried out enzymatically with esterase from hog liver or from Pleurotus ostreatus.

REFERENCES:
Iriuchijima et al; Agric. Biol. Chem., 45(6) (1981), pp. 1389-1392.

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