Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-09-18
1987-06-02
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 85, 424101, 514 2, 514802, 514834, 436548, 525 541, C07G 700
Patent
active
046705430
ABSTRACT:
The invention relates to a process for producing FVIII/vWF complexes for therapeutical use possessing both haemophilic A activity and Willebrand activity as well as a high degree of purity, such process substantially comprising the steps of fixing the FVIII/vWF complex in physiological conditions on a particular monoclonal antibody and releasing said complex by means of a suitable elution medium having no effct on the functions of the FVIII/vWF complex but able to dissociate the bonds linking the selected monoclonal anitbody to the FVIII/vWF complex, then collecting the latter in a highly purified form.
REFERENCES:
patent: 4361509 (1982-12-01), Zimmerman et al.
Chemical Abstracts, vol. 96, No. 19, May 10, 1982, p. 571, No. 160565y, Columbus, Ohio, US; D. N. Fass et al.: "Monoclonal Antibodies to Porcine Factor VIII Coagulant and Their Use in the Isolation of Active Coagulant Protein".
Biological Abstracts, vol. 78, No. 8, 1984, Philadelphia, Pa., H. V. Stel et al; "Characterization of 25 Monoclonal Antibodies to Factor VIII-von Willebrand Factor: Relationship Between Ristocetin--Induced Platelet Aggregation and Platelet Adherence to Subendothelium": Blood 63(6): 1408-1415, 1984.
Chem. Abstracts, vol. 103, No. 5, p. 376, 1985, Columbus, Ohio, P. Avner et al. "Monoclonal Anitbodies Against the Human Factor VIII von Willebrand Molecule: Characterization and Potential for Screening of von Willebrand Patients" Dev.Biol.Stand. 1984.
Bourgois Alain
Delezay Marylene
Fert Vincent
Immunotech
Kight John
Nutter Nathan M.
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