Process for obtaining chemically defined and reproducible polyde

Details Process for obtaining chemically defined and reproducible polyde Process for obtaining chemically defined and reproducible polyde

1989-07-05

1991-01-15

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07N 100

Patent

active

049855522

ABSTRACT:
By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxyribonucleotide, known as Defibrotide is obtained. Defibrotide has the following formula of random sequence:

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patent: 4693995 (1987-09-01), Prino et al.
Cizmeci et al., The Chemical Abstracts, 107:147033z (1987).

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