Process for obtaining cellular protein having anti-HIV activity

Details Process for obtaining cellular protein having anti-HIV activity Process for obtaining cellular protein having anti-HIV activity

1991-02-22

1994-09-13

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

435 703, 435 704, 530350, A61K 3702, C07K 114, C07K 302, C07K 1506

Patent

active

053469887

ABSTRACT:
A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity, as measured by gel filtration analysis, is within the range of about 7,000 to about 12,000 daltons.

REFERENCES:
patent: 4683199 (1987-07-01), Palladino
patent: 5039794 (1991-08-01), Wier et al.
patent: 5236829 (1993-08-01), Farber
P. K. Lai, "Modification of human immunodeficiency viral replication . . . ," AIDS Research and Human Retroviruses, vol. 6, No. 2, Sep. 3, 1986.
Lai et al., AIDS Research and Human Retroviruses, "Modification of Human Immuno-Deficiency Viral Replication by Pine Cone," 6:205-217, (1990).
Shinazi et al., Antimicrob. Agents Chemother., "Activities of 3'-Azido-3'-Deoxythymidine Nucleotide Dimers in Primary . . . " 34:1061-1066 (1990).
Cooley et al., New England J. of Med., "Once Daily Administration of 2',3'-Dideoxyinosine (ddI) in Patients with Acquired . . . " 322:1340-1345 (1990).
Harris et al., "Protein purification methods", published 1989, IRL Press, pp. 9-10 and 57-60.

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