Process for obtaining cellular protein having anti-HIV activity

Details Process for obtaining cellular protein having anti-HIV activity Process for obtaining cellular protein having anti-HIV activity

1994-08-04

1996-01-02

Russel, Jeffrey E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 704, 514 21, A61K 3817, C12P 2100

Patent

active

054807824

ABSTRACT:
A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity, as measured by gel filtration analysis, is within the range of about 7,000 to about 12,000 daltons.

REFERENCES:
patent: 4683199 (1987-07-01), Palladino et al.
patent: 5039794 (1991-08-01), Wier et al.
patent: 5236829 (1993-08-01), Farber
patent: 5346988 (1994-09-01), Nonoyama et al.
Date stamp pages of AIDS Research and Human Retroviruses, vol. 6, No. 2 (1990).
AIDS Research and Human Retroviruses, vol. 6, No. 2, issued 1990, Lai et al, "Modification of Human Immunodeficiency Viral Replication . . . ", pp. 205-217.
Antimicrob, Agents Chemother., vol. 34, issued 1990, Shinazi et al, "Activities of 3'-Azido-3'-Deoxythymidine Nucleotide . . . ", pp. 1061-1066.
New England J. Med., vol. 322, issued 1990, Cooley et al, "Once Daily Administration of 2',3'-Dideoxyinosine . . . ", pp. 1340-1345.
Harris et al, Protein purification methods, published 1989 by IRL Press (New York), pp. 9-10 and 57-60.

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