Process for obtaining betulinic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

Reexamination Certificate

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Reexamination Certificate

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06943260

ABSTRACT:
The invention relates to an improved process for obtaining highly pure, crystalline betulinic acid from a methanolic extract of ground plane tree cortex and/or plane tree bark, as well as highly pure crystalline betulinic acid which is solvated with one equivalent of ethanol.

REFERENCES:
patent: 6175035 (2001-01-01), Draeger et al.
patent: 6264998 (2001-07-01), Ramadoss et al.
patent: 6569842 (2003-05-01), Pezzuto et al.
patent: 356057780 (1981-05-01), None
patent: WO-0110885 (2001-02-01), None
patent: WO-0110885 (2001-02-01), None
Bruckner et al., “Occurrence of Betulinic Acid in the Bark of the Plane Tree.” J. Chem. Soc., (181), pp. 948-951, 1948.
V. Bruckner et al; “Occurence of Betulinic Acid in the Bark of the Plane Tree”; J. Chem Soc. (1948) No. 181; pp. 948-951.
Robertson, A. et al; Polyterpenoid Compounds. Part. I. Betulic Acid from Comus florida, L.; Journal of Chemical Society; 1939; pp. 1267-1273.

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