Process for obtaining an antiepileptic agent

Details Process for obtaining an antiepileptic agent Process for obtaining an antiepileptic agent

2007-11-06

2007-11-06

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S518000, C514S422000, C514S424000

Reexamination Certificate

active

10544967

ABSTRACT:
A process for obtaining the pharmaceutical active ingredient, levetiracetam, by means of deaminomethylation of a sufficiently pure enantiomer intermediate (S)-(II), or by means of deaminomethylation of an addition salt thereof with an acid, wherein R1and R2are either the same or different (C1-C6)-alkyl radicals, or else R1and R2together with the nitrogen atom to which they are bonded form a radical selected from the group consisting of 1-pyrrolidinyl, 1-piperidinyl, 1-morpholinyl, 1-piperazinyl and 1-[4-(C1-C4)-alkylpiperazinyl]. The invention also comprises preparing the sufficiently pure enantiomer intermediate (S)-(II) by treating the corresponding chemically new racemic intermediate (II) with an amine resolving agent, followed by selective crystallisation of a diastereoisomeric salt thereof. It is useful for obtaining levetiracetam on an industrial scale and involves neither hydrogenation nor chromatography

REFERENCES:
patent: 6107492 (2000-08-01), Futagawa et al.
patent: 6124473 (2000-09-01), Cavoy et al.

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