Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1974-12-03
1976-12-21
Moyer, Donald B.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
424 98, 424103, 424101, 424 94, 260112R, A61K 3548
Patent
active
039989470
ABSTRACT:
A process for obtaining a plasminogen activator involves treating an acetone extract powder of organs of animals, such as the lungs and kidneys of pigs, calves, bullocks, horses, lambs or sheep or the ovaries of porcine, bovine or ovine animals, by suspension in an aqueous saline solution, taking up the precipitate obtained in an aqueous saline solution of greater ionic strength and lower pH-value, decanting the solution and precipitating therefrom at acidic pH by adding a salt or an organic solvent, further taking up the precipitate obtained in water or a saline solution, followed by repeated precipitation by adding a salt at a somewhat higher pH-value, finally taking up the precipitate obtained in water and dialyzing the solution, and optionally purifying the solution obtained.
The activator obtained may be used as a medicament.
REFERENCES:
patent: 3234106 (1966-02-01), Hink et al.
patent: 3743722 (1973-07-01), Nolan
Kok et al., Biochemistry, vol. 8, No. 1, pp. 79-86 (1969).
Bachmann et al., Biochemistry, vol. 3, p. 1578 (1964).
White et al., Biochemistry, vol. 5, No. 7, pp. 2160-2169 (1966).
Keio Journal of Medicine, vol. 13, No. 4, Dec. 1964 pp. 187-194.
Brockway et al., J. of Biological Chemistry, vol. 246, No. 14 Issue of July 25, 1971, pp. 4641-4647.
Science, vol. 170, No. 3959, Nov. 13, 1970, pp. 1095 & 1096.
D'Hinterland Lucien Dussourd
Durand Jacques
Normier Gerard
Pradayrol Lucien
Levine Alan H.
Moyer Donald B.
Pierre Fabre S.A.
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