Process for obtaining 17β-(substituted)-3-oxo-Δ...

Details Process for obtaining 17β-(substituted)-3-oxo-Δ... Process for obtaining 17β-(substituted)-3-oxo-Δ...

2006-06-06

2006-06-06

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S047000

Reexamination Certificate

active

07057045

ABSTRACT:
The 17β-(substituted)-3-oxo-Δ1,2-4-azasteroids (I), wherein R1is C1–C4alkyl, OR2, wherein R2is a C1–C4alkyl radical, or NR3R4, wherein R3and R4, equal or different, represent hydrogen or a C1–C4alkyl radical, can be obtained by means of a process comprising cleaving the oxazolidinedione ring present in a 2-(substituted)-3-hydroxyoxazolidinedione of formula (IV), wherein R5is Br or trichloromethylsulfonyl, and removing the substituent at position 2, to form a double bond at position 1,2. Some compounds (I) are testosterone-5α-reductase inhibitors and can be used in the treatment of hyperandrogenic disorders.

REFERENCES:
patent: 5021575 (1991-06-01), King et al.

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