Process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cycl

Details Process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cycl Process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cycl

1998-06-02

1999-11-30

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540465, 540450, C07D48722

Patent

active

059945362

ABSTRACT:
The invention relates to the process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene, the corresponding mono- and 1,7-bis-N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li-salt complexes as intermediate products in the process and the use of the N-(6-hydroxy-2,3-dimethyl-1,3-dioxepan-5-yl)-1,4,7,10-tetraazacyclododecan e-LiCl complex for the production of gadobutrol [Gd ocmplex of N-(1-hydroxy-methyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane].

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patent: 5747000 (1998-05-01), Platzek et al.
Tilstam et al., Chem. Abst., vol. 121:57541y., 1994.
Chemical Abstract, vol. 124, No. 25 (Jun. 17, 1996) p. 1324, Abstract No. 343242, 1996, Intrenational Search Report.

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