Process for modification of implant surface with bioactive conju

Details Process for modification of implant surface with bioactive conju Process for modification of implant surface with bioactive conju

1996-06-28

1998-10-20

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

427 2, 427327, 427337, 427338, 530350, 530395, 530402, 20412995, 106124, 623 16, 514 12, A61K 3818, A61K 3839, A61F 228, B05D 304

Patent

active

058246517

ABSTRACT:
The present invention relates to a process for the covalent coating of implants with a bioactive conjugate, which comprises the steps of: a) cleaning a metal implant surface from contaminants by deoxidation with potentiostatic electrochemical polishing in a solution selected from ethanol, perchloric acid-butanol-methanol solution, H.sub.2 O.sub.2 --NaCl--NaH.sub.2 PO.sub.4 or by chemical cleaning with a solution selected from the group consisting of HF/HNO.sub.3, H.sub.2 O.sub.2 /H.sub.2 SO.sub.4 and H.sub.2 O.sub.2 /KOH; b) coating the cleaned implant surface of step a) with a bioactive conjugate, wherein the conjugate has the following structural Formula I:

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