Process for micronizing slightly-soluble drug

Details Process for micronizing slightly-soluble drug Process for micronizing slightly-soluble drug

1990-08-03

1993-04-13

Page, T. K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 47, 424451, 424464, A61K 914, A61K 916

Patent

active

052021297

ABSTRACT:
A process for micronizing a slightly-soluble drug characterized by subjecting a mixture of said drug and a sugar or sugar alcohol to high-speed stirring comminution or impact comminution in order to produce a micronized drug having an average diameter of less than about 2-3 mm. Also provided is a pharmaceutical formulation which comprises the micronized drug.

REFERENCES:
patent: 4753800 (1988-06-01), Mozda
Remingtons Pharmaceutical Sciences, 1988 Edition Mack Publishing Co.
"Optimization of In Vitro Availability of Diazepam" by S. Leucuta et al., Clujul Medical 1982, vol. LV-No. 1.
"Properties and Dissolution of Drugs Micronized By Crystallization From Supercritical Gases", by H. Loth et al., International Journal of Pharmaceutics, vol. 32, 1986, pp. 265-267.
H. Sekikawa et al., Chem. Pharm. Bull., vol 26, pp. 3033-3039 (1978).
Nature, vol. 193, pp. 588-589 (1962).
N. Kaneniwa et al., Chem. Pharm. Bull., vol. 23, pp. 2973-2986 (1975).
Yakugaku Zasshi, vol. 101, No. 8, pp. 723-732 (1981).

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