Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1994-02-03
1997-07-15
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
264 432, 264 433, 264 46, 424439, 424488, 424494, 435179, 514866, 514963, 514965, A61K 958, A61K 962, B01J 1312
Patent
active
056480997
ABSTRACT:
Oxalate-degrading enzymes and bacteria were encapsulated for both enteric and intraperitoneal administration. We have shown that via alginate microencapsulation of Oxalobacter formigenes, enzymatic activity was retained for several months. A new process was developed which strengthened the alginate microcapsules and their tolerance to citrate treatment. Much smaller (30-50 .mu.m) alginate microcapsules were made for injection as means of implantation. For oral administration, multi-encapsulated microspheres of cellulose acetate phthalate in poly-2-vinylpyridine (pKa=3.5) were prepared to protect the enzymes from gastric juices.
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Batich Chris
Vaghefi Farid
Lovering Richard D.
University of Florida
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