Process for microbial production of an optically active 3-(3,4-d

Details Process for microbial production of an optically active 3-(3,4-d Process for microbial production of an optically active 3-(3,4-d

1984-11-05

1987-10-13

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435280, 435826, 435886, 435908, C12P 1306, C07P 4100

Patent

active

046998799

ABSTRACT:
N-acyl-DL-3-(3,4-dihydroxyphenyl)serine or a catecholic hydroxyl-protected derivative thereof is stereospecifically de-acylated by reaction with a microorganism of the genus Streptomyces or Streptoverticillium having an acylase or with an extract of said microorganism containing said acylase, to produce L-3-(3,4-dihydroxyphenyl)serine or the hydroxyl-protected derivative thereof, with the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound remaining unaltered. The L-3-(3,4-dihydroxyphenyl)serine compound so produced can be separated from the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound owing to the difference in the properties of them.

REFERENCES:
patent: 3386888 (1968-06-01), Chibata et al.
patent: 3546070 (1970-12-01), Yoshinaga et al.
patent: 3669837 (1972-06-01), Parcell
patent: 3841966 (1974-10-01), Soichiro Asai et al.

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