Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1992-12-07
1994-06-07
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 18, 435 34, 536 111, 5361231, 53612312, C12Q 137, C12Q 134, C07H 306, C08B 3718
Patent
active
053188934
ABSTRACT:
Measuring of endotoxin using a reaction of a horseshoe crab hemocyte lysate with endotoxin in a solution can be carried out in the presence of a water-soluble polysaccharide containing .beta.-1,3-glucosidic linkage and/or a water-soluble polysaccharide derivative containing .beta.-1,3-glucosidic linkage.
REFERENCES:
patent: 4038029 (1977-07-01), Teller et al.
patent: 5047353 (1991-09-01), Tsuchiya et al.
patent: 5155032 (1992-10-01), Tanaka et al.
patent: 5179006 (1993-01-01), Matuura et al.
"Gelatin of Limulus Amoebocytel Lysate by an Antitumor (1.fwdarw.3)-.beta.-D-Glucan", Kakinuma et al., Biochemical and Biophysical Research Communications, vol. 101, No. 2, 1981, Jul. 30, 1981, pp. 434-439.
"Bacterial Endotoxin, Chemical, Biological and Clinical Aspects", Homma et al., Verlag Chemie, pp. 365-382.
"A New Chromogenic Endotoxin-Specific Assay Using Recombined Limulus Coagulation Enzymes and its Chemical Applications", Obayashi et al, Clinca Chemica Acta, 149 (1985), pp. 55-65.
Soederhaell, et al., "The affects of .beta.1,3-glucans on blood coagulation and amebocyte release in the horseshoe crab, Limulus polyphemus," Biol. Bull 169:661-74 (1985) (Abst Only).
Hodes et al., "Reaction of fungal products with Amebocyte Lysates of the Japanese horseshoe crab, Tacypleus tridentatus," J. Clin Micro 25:1701-1704 (1987).
Matuura Shuji
Tsuchiya Masakazu
Nucker Christine M.
Wako Pure Chemical Industries Ltd.
Woodward M. P.
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