Process for measuring complement activity and reagent used there

Details Process for measuring complement activity and reagent used there Process for measuring complement activity and reagent used there

1996-11-26

1998-12-29

Duffy, Patricia

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436528, 436821, 436829, 435975, 5303871, 5303889, 5303891, G01N 3353

Patent

active

058540822

ABSTRACT:
A reagent composition comprising (a) liposomes encapsulating a marker therein, immobilizing a hapten on liposome membranes and having a size in the range of 100 to 500 nm in terms of mean particle size plus twice the standard derivation, and (b) an antibody to the hapten is effective for measuring human complement activity easily and precisely with excellent storage stability.

REFERENCES:
Kinsky et al., Complement-Dependent Damage to Liposomes Prepared from Pure and Forssman Hapten, "Biochemistry" vol. 8, No. 10, pp. 4149-4158, (1969).
Geiger et al., Immunochemical Determination of Ganglioside GM, By Inhibition of Complement-Dependent Liposome Lysis, "Journal of Immunological Methods", 17, pp. 7-19, (1977).
Bowden et al., Homogeneous, Liposome-Based Assay for Total Complement Activity in Serum, "Clinical Chemistry", vol.32, No. 2, pp 275-278, (1986).
Derwent Publications Ltd., GB; JP A 01 155 271--Jun. 19, 1989, Abstract.
Patent Abstracts of Japan; Tomioka Kanji et al.; Jun. 7, 1994, JP A 6 160 390--Abstract.
Patent Abstracts of Japan; Kanegafuchi Chem Ind. Co. Ltd., Sep. 13, 1989, JP-A-01 229 970--Abstract.
Biochemica et Biophysica Acta; "Biomembranes", vol. 557, No. 1, Oct. 19, 1979 Amsterdam, pp. 9-23.
Masaki et al, J. Immurol. Methods, 123 (1):19-24 Sep. 29, 1989.
Paul et. "Fundamental Immunology", 1985 by Raven Press NY NY p. 680.
Sigma Chemical Company outa logue, 1992 p. 282-283.
Vance et al "The Biochemistry of Lipids and membranes", 1985 by Benjamin/Cummings Publishing Co Inc, Calfornina p. 36-39.

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