Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-08-02
1993-10-12
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530416, C07K 322, C07K 1506
Patent
active
052527107
ABSTRACT:
The invention relates to a process for manufacturing von Willebrand factor. This process comprises the selective adsorption of factor VIIIc on the gel of a first ion exchange chromatography column, the von Willebrand factor being contained in the non-retained fraction, and is characterized in that the non-retained fraction is treated so as to adsorb the von Willebrand factor selectively on the gel of a second chromatography column, the factor then being desorbed and being obtained with a very high purity. The invention enables a von Willebrand factor of very high purity, largely devoid of antihaemophilic factor VIIIc and of inactivators such as Tween and TNBP, as well as of the main plasma contaminants, to be obtained
REFERENCES:
patent: 4170590 (1979-10-01), Stephan et al.
patent: 4670543 (1982-06-01), Bourgois et al.
patent: 4774323 (1988-09-01), Newman et al.
patent: 4883598 (1989-11-01), Riethorst et al.
British Journal of Haematology, vol. 43, issued 1979, Austen, "The Chromatographic Separation of Factor VIII . . . ", pp. 669-674.
DBA Abstract, PCT WO89-12065, Dec. 14, 1989.
Dazey Bernard
Hamsany Mohamed
Vezon Gerard
Association d'Aquitaine pour le Developpment de la Transfusion S
Russel Jeffrey E.
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