Process for manufacturing tylosin derivatives

Details Process for manufacturing tylosin derivatives Process for manufacturing tylosin derivatives

1978-02-27

1980-05-06

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435898, C12P 1962, C12R 155

Patent

active

042018439

ABSTRACT:
New tylosin derivatives having at least one acyl group at the 3- and 4"-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4"-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.

REFERENCES:
patent: 2943024 (1960-06-01), Ninet et al.
patent: 3817836 (1974-06-01), Theriault et al.
The Merck Index, pp. 1260 and 1261, 9th Edition.

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