Process for manufacturing purified phosphorodiamidite

Details Process for manufacturing purified phosphorodiamidite Process for manufacturing purified phosphorodiamidite

2006-06-06

2006-06-06

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

Reexamination Certificate

active

07057062

ABSTRACT:
A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from the solubilized phosphorodiamidite, and removing the non-polar organic solvent from the phosphorodiamidite.

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