Process for manufacturing phenoxylactic acids, their derivatives

Details Process for manufacturing phenoxylactic acids, their derivatives Process for manufacturing phenoxylactic acids, their derivatives

1979-08-17

1982-06-01

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 61, 560 73, 560106, 560228, 560254, 562470, 562471, 564175, 544170, 546250, 260465F, C07C 6976

Patent

active

043329594

ABSTRACT:
The process is for the manufacture of phenoxylactic acids and their derivatives of the general formula: ##STR1## (in which R.sub.1 and R.sub.2, identical or different, can represent hydrogen atoms, methyl residues, methoxy groups or halogens; Y represents an OH or O--CO--R.sub.3 group with R.sub.3 representing either an aliphatic residue possibly substituted by a halogen, or an aromatic residue possibly substituted on the nucleus by one or several methyl, methoxy, halogen groups or lastly a heterocyclic group; Z represents OH group or an ##STR2## with R.sub.4 representing an alkyl or aryl radical and R.sub.5 hydrogen or an alkyl radical, NR.sub.4 R.sub.5 possibly also representing the morpholinyl radical). A cyanhydrin is subjected to a Ritter reaction (reaction with tert. butanol or isobutene in the presence of an acid). The resulting compound is hydrolyzed to obtain the corresponding acid, and if desired, this acid is subjected to conventional reactions for preparing ester-acids, ester-amides or corresponding amides.

REFERENCES:
patent: 2719176 (1955-09-01), Coover
patent: 3113964 (1963-12-01), Faricas et al.
patent: 3166588 (1965-01-01), Johnson et al.
patent: 3190917 (1965-06-01), Johnson et al.
patent: 3277160 (1966-10-01), Weil
patent: 3641123 (1972-02-01), Hayman et al.
Krauch, H. et al., "Organic Name Reactions", John Wiley & Sons, N. Y., p. 391, 1964.
Noller, C. R., "Chem. of Organic Cmpds.", W. B. Saunder, p. 276, 1968.

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