Process for manufacturing paroxetine solid dispersions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514937, A61K 31445

Patent

active

059554754

ABSTRACT:
Solid dispersions of poorly soluble drugs are disclosed which are prepared using a solvent or fusion process. Such dispersions are manufactured with the free base of the drug, specifically paroxetine free base, an oil, allowing for a low temperature for the fusion process, decreased organic solvent volumes for the solvent process and the formation of a paroxetine salt during the solid dispersion manufacture process.

REFERENCES:
patent: 4007146 (1977-02-01), Christuensen et al.
patent: 4721723 (1988-01-01), Barnes et al.
patent: 4933360 (1990-06-01), Pandit et al.

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