Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-30
1999-09-21
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514937, A61K 31445
Patent
active
059554754
ABSTRACT:
Solid dispersions of poorly soluble drugs are disclosed which are prepared using a solvent or fusion process. Such dispersions are manufactured with the free base of the drug, specifically paroxetine free base, an oil, allowing for a low temperature for the fusion process, decreased organic solvent volumes for the solvent process and the formation of a paroxetine salt during the solid dispersion manufacture process.
REFERENCES:
patent: 4007146 (1977-02-01), Christuensen et al.
patent: 4721723 (1988-01-01), Barnes et al.
patent: 4933360 (1990-06-01), Pandit et al.
Chang Sou-Chan
Hein, II William A.
Krape Philip J.
Teleha Christopher A.
Endo Pharmaceuticals Inc.
Fein Michael B.
Schenkman Leonard
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