Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1988-07-01
1991-08-27
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
424423, 514 21, C07K 1520
Patent
active
050434268
ABSTRACT:
The invention relates to a process for manufacturing organized collagen structures, particularly of human origin and the organized collagen structures corresponding thereto. These organized structures may be either fibres or membranes. According to the process, a specimen of animal or human tissue is ground in a saline solution after washing and aseptization, in order to solubilize the collagen contained in said specimen. There is then added to the extract thus obtained, which is composed of a minimum quantity of collagen fibrils and which is free of non-fibrillary collagen precipitate, a catalyst promoting the reconstitution of collagen fibres. Following a maturation process, the reconstituted organized structures are separated from the aqueous medium by centrifuging, and are then washed, aseptized, conditioned, lyophilized and sterilized. Among the organized structures obtained, the collagen fibers appear in the isolated state, separated from their original cellular tissue, in the form of a web (35), ready for use. They display a periodicity of transverse striations (37) comprised between 68 nm and 72 nm.
REFERENCES:
patent: 4242291 (1980-12-01), Hughes
Trommsdorf, Chem. Abst., vol. 85, 1976, 51730a.
Diatech S. A.
Koh Choon P.
Schain Howard E.
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