Process for manufacturing opioid analgesics

Details Process for manufacturing opioid analgesics Process for manufacturing opioid analgesics

2006-07-04

2006-07-04

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07071336

ABSTRACT:
Oxycodone is manufactured in high yields and with a high purity using a composition including a thebaine component into 14-hydroxycodeinone and then reduction of 14-hydroxycodeinone to oxycodone.

REFERENCES:
patent: 4045440 (1977-08-01), Rapoport et al.
patent: 4472253 (1984-09-01), Schwartz
patent: 4795813 (1989-01-01), Schwartz
patent: 5112975 (1992-05-01), Wallace
patent: 6008355 (1999-12-01), Huang et al.
patent: 6067749 (2000-05-01), Fist et al.
patent: 6090943 (2000-07-01), Mudryk et al.
patent: 6177567 (2001-01-01), Chiu et al.
patent: 0 943 617 (1999-09-01), None
Kranig et al., “Optimization of the Synthesis of Oxycodone and 5-Methyloxycodone”, Arch. Pharm. Med. Chem. 329, pp. 325-326, 1996.
Brown I., et al., “Oxidation Products from Codeine,” Journal of The Chemical Society, Oct. 1960, pp. 4139-4140.
Coop, A. et al., “A Novel Synthesis of Thebaine from Codeine,” Heterocycles, vol. 49 (1998), pp. 43-47.
Hauser, F.M. et al., “Hydroxycodeinone. An Improved Synthesis,” Journal of Medicinal Chemistry, vol. 17, No. 10, (1974), p. 1117.
Krasnig, R. et al., “Optimization of the Synthesis of Oxycodone and 5-Methyloxycodone,” Arch. Pharm. Pharm. Med. Chem., (1996), pp. 325-326.
Lijima, I et al., “The Oxidation of Thebaine with m-Chloroperbenzoic Acid,” Helvetica Chimica Acta, vol. 60- (1977), pp. 2135-2137.
Merck Index, 13th Edition (2001), pp. 1245-1246.

Affiliated with

Also associated with

Rating

Process for manufacturing opioid analgesics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for manufacturing opioid analgesics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for manufacturing opioid analgesics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3560269