Process for manufacturing morpholino-nucleotides, and use...

Details Process for manufacturing morpholino-nucleotides, and use... Process for manufacturing morpholino-nucleotides, and use...

2006-09-12

2006-09-12

Lewis, Patrick (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C536S018700, C536S022100, C536S023100, C536S025300, C536S026600, C536S028100, C536S028600, C536S055300, C536S026100, C544S242000, C544S066000, C544S180000, C544S224000, C544S233000, C544S235000

Reexamination Certificate

active

07105661

ABSTRACT:
The invention relates to the use of morpholino-nucleosides of formula:in which R1represents a nucleic base and R2represents a group corresponding to one of the following formulae:in-line-formulae description="In-line Formulae" end="lead"?—(CH2)n—NH2—(CH2)n—SHin-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?—(CH2)n—COOH —(CH2)n—OHin-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?—(CH2)n—NH—R3—(CH2)n—SR3in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?—(CH2)n—CO—R3—(CH2)n—OR3in-line-formulae description="In-line Formulae" end="tail"?in which n is an interger ranging from 1 to 12 and R3is a group derived from a label, from a protein, from an enzyme, from a fatty acid or from a peptide, as chain terminators in a process of DNA or RNA sequencing by the Sanger method, or for the labelling of DNA or RNA fragments.

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