Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1994-04-04
1996-07-02
Shippen, Michael L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
558 48, C07C22900
Patent
active
055324100
ABSTRACT:
L-(-)-carnitine is prepared from D-(+)-carnitinamide by (a) reacting D-(+)-carnitinamide in an acid medium with a straight or branched chain aliphatic alcohol thereby forming D-(+)-carnitine ester, (b) acylating the D-(+)-carnitine ester with an anhydride R.sub.2 O, thereby forming an acylated ester intermediate, (c) acid hydrolyzing the ester group of the acyl carnitine ester thereby obtaining acyl D-(+)-carnitine, (d) lactonizing the acyl D-(+)-carnitine to a lactone of L-(-)-carnitine, and (e) reacting the lactone with base thereby forming L-(-)-carnitine.
REFERENCES:
patent: 3096368 (1963-07-01), Binon
patent: 4413142 (1983-11-01), Fiorini
Bernabei Ida
De Angelis Francesco
Giannessi Fabio
Scafetta Nazareno
Tinti Maria O.
Shippen Michael L.
Sigma-Tau Industrie Farmaceutiche Ruinite S.p.A.
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