Process for manufacturing high density cell cultures

Details Process for manufacturing high density cell cultures Process for manufacturing high density cell cultures

1976-04-08

1977-12-13

Penland, R. B.

Textiles: fiber preparation

195 33, 195 82, 195 96, 195117, C12B 100

Patent

active

040627276

ABSTRACT:
A process for biosynthetically producing cells in a liquid fermentation media comprised of a carbon source, and a growth medium containing oxygen and other essential cell nutrients, to obtain a biomass for harvesting. The carbon source and each of the other essential cell nutrients are added, incrementally or continuously, to the fermentation media, and each required nutrient is maintained at essentially the minimum level needed for efficient assimilation by the growing cells, in accordance with a predetermined cell growth curve based on the metabolic or respiratory function of the cells which convert the carbon source to a biomass. The process constitutes a marked improvement in accelerating and increasing cell production in a given fermentation system. In its preferred aspects, the nutrients are added within the fermentation media below the foam level which forms on top of the fermentation broth. A particularly preferred fermentation system embodies the preparation, in a nutrient medium, of comestible, digestible protein from a carbon source, suitably a hydrocarbon or carbohydrate, particularly delignified cellulose. A cellulase-elaborating microorganism, suitably a fungii, yeast or bacteria, particularly a microorganism of the genus Cellulomonas (ATCC-21399) used alone, or in compatible association with another microorganism, is cultivated within the medium which contains the carbon source.

REFERENCES:
patent: 2822319 (1958-02-01), Monod
patent: 3342695 (1967-09-01), Felsenfeld
patent: 3761355 (1973-09-01), Callihan et al.

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