Process for manufacturing DTPA-bis amide magnetic resonance imag

Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing

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C07F 500

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active

055083889

ABSTRACT:
Processes for manufacturing diethylenetriaminepentaacetic acid ("DTPA") bis(amide) magnetic resonance imaging ("MRI") agents are disclosed. Specifically, processes for manufacturing [N,N"-Bis[N-(2-methoxyethyl)carbamoylmethyl]diethylenetriamine-N,N',N"-tri acetato]gadolinium(III) are disclosed.

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patent: 4826673 (1989-05-01), Dean et al.
patent: 5130120 (1992-07-01), Weber
patent: 5137711 (1992-08-01), Weber et al.
Merck Index, 10th Edition, 1983, p. 10, 749.
Riddick et al., Organic Solvent, 1970, pp. 798-799.

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