Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1995-11-07
1998-03-31
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D50318, A61K 3142
Patent
active
057340480
ABSTRACT:
According to the present invention, a process for manufacturing alkali metal salt of clavulanic acid wherein impure clavulanic acid in aqueous solution is extracted by a solvent mixture of ketone and alkyl acetate under acidic condition, treated in a conventional manner, and a solution of alkali metal salt of alkanoic acid dissolved in ketone or alkanol solvent is added to obtain pure alkali metal salt of clavulanic acid is provided.
Since the process according to the present invention omits a step of formation of amine salt, an economic and simple method for manufacturing alkali metal salt of clavulanic acid in a high yield without excessive use of solvent is provided.
REFERENCES:
patent: 4110165 (1978-08-01), Cole et al.
patent: 5498788 (1996-03-01), Zmitek
Choi Gang Sun
Choi Nam Hee
Kim Jung Woo
Lee Don Wha
Berch Mark L.
Chong Kun Dang Corp.
Nath, Esq. Gary M.
Orzechowski Karen
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